Research
Explore published research, case studies, and presentations from the Enable Medicine team.

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April 6, 2023
Publication
Non-small cell lung cancer (NSCLC)
Tumor microenvironment (TME)
Multiplexed imaging
Multi-omic and spatial dissection of immunotherapy response groups in non-small cell lung cancer
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Wiley

April 6, 2023
Publication
Non-small cell lung cancer (NSCLC)
Tumor microenvironment (TME)
Multiplexed imaging
Multi-omic and spatial dissection of immunotherapy response groups in non-small cell lung cancer
READ NOW
Wiley
Multiplexed imaging
NSCLC multi-omics

April 1, 2023
Case study
Patient stratification
Ulcerative Colitis
Multiplexed imaging
Multiplex imaging and analysis using the Enable Cloud Platform to predict TNF inhibitor response in ulcerative colitis patients
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Enable Medicine

April 1, 2023
Case study
Patient stratification
Ulcerative Colitis
Multiplexed imaging
Multiplex imaging and analysis using the Enable Cloud Platform to predict TNF inhibitor response in ulcerative colitis patients
READ NOW
Enable Medicine
Multiplexed imaging
Enable multiplex analysis

February 21, 2023
Poster
Prostate cancer
Clinical trials
High-plex imaging
A phase 2 study of Ibrutinib as neoadjuvant therapy in patients with localized prostate cancer
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Enable Medicine

February 21, 2023
Poster
Prostate cancer
Clinical trials
High-plex imaging
A phase 2 study of Ibrutinib as neoadjuvant therapy in patients with localized prostate cancer
READ NOW
Enable Medicine
Multiplexed imaging
High-plex imaging
CODEX
Ibrutinib patient stratification

January 20, 2023
Publication
Ulcerative Colitis
Patient stratification
Multiplexed imaging
A tissue atlas of ulcerative colitis revealing evidence of sex-dependent differences in disease-driving inflammatory cell types and resistance to TNF inhibitor therapy
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Science Advances

January 20, 2023
Publication
Ulcerative Colitis
Patient stratification
Multiplexed imaging
A tissue atlas of ulcerative colitis revealing evidence of sex-dependent differences in disease-driving inflammatory cell types and resistance to TNF inhibitor therapy
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Science Advances
Multiplexed imaging
TNF inhibitor resistance

November 17, 2022
Publication
Atherosclerosis
Mechanisms of action
Single-cell transcriptomics
Single-cell transcriptomic consensus of endothelial changes induced by matrix stiffness and the association with atherosclerosis
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Wiley

November 17, 2022
Publication
Atherosclerosis
Mechanisms of action
Single-cell transcriptomics
Single-cell transcriptomic consensus of endothelial changes induced by matrix stiffness and the association with atherosclerosis
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Wiley
Multiplexed imaging
Single-cell transcriptomics
Single-cell transcriptomics

November 10, 2022
Publication
Tumor microenvironment (TME)
Patient stratification
Neural network
Graph deep learning for the characterization of tumor microenvironments from spatial protein profiles in tissue specimens
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Nature Biomedical Engineering

November 10, 2022
Publication
Tumor microenvironment (TME)
Patient stratification
Neural network
Graph deep learning for the characterization of tumor microenvironments from spatial protein profiles in tissue specimens
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Nature Biomedical Engineering
Spatial proteomics
Multiplexed imaging
CODEX
Neural network
Tissue protein profile

November 7, 2022
Poster
Clinical trials
Biomarkers
High-plex imaging
Biomarker correlates of clinical response with FLT3L/Nivo backbone treatment in the multi-cohort phase 1 PORTER platform trial in metastatic, castration-resistant prostate cancer patients
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Society for Immunotherapy of Cancer

November 7, 2022
Poster
Clinical trials
Biomarkers
High-plex imaging
Biomarker correlates of clinical response with FLT3L/Nivo backbone treatment in the multi-cohort phase 1 PORTER platform trial in metastatic, castration-resistant prostate cancer patients
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Society for Immunotherapy of Cancer
Multiplexed imaging
CODEX
High-plex imaging
Biomarkers for clinical response

July 22, 2022
Video presentation
Biomarkers
Tissue microenvironment
In silico multiplexed imaging
7-UP: generating in silico CODEX from a small set of immunofluorescence markers
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Enable Medicine

July 22, 2022
Video presentation
Biomarkers
Tissue microenvironment
In silico multiplexed imaging
7-UP: generating in silico CODEX from a small set of immunofluorescence markers
READ NOW
Enable Medicine
Multiplexed imaging
In silico multiplexed imaging
CODEX
7-UP

October 7, 2021
Publication
Tumor microenvironment (TME)
Pancreatic cancer
Multiplexed imaging
Activating immune recognition in pancreatic ductal adenocarcinoma via autophagy inhibition, MEK blockade, and CD40 agonism
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Gastroenterology

October 7, 2021
Publication
Tumor microenvironment (TME)
Pancreatic cancer
Multiplexed imaging
Activating immune recognition in pancreatic ductal adenocarcinoma via autophagy inhibition, MEK blockade, and CD40 agonism
READ NOW
Gastroenterology
Multiplexed imaging
Immune recognition